HIGH-THROUGHPUT VIRTUAL SCREENING WITH E-PHARMACOPHORE AND MOLECULAR SIMULATIONS STUDY IN THE DESIGNING OF PANCREATIC LIPASE INHIBITORS

High-throughput virtual screening with e-pharmacophore and molecular simulations study in the designing of pancreatic lipase inhibitors

Ganesh Kumar Veeramachaneni, K Kranthi Raj, Leela Madhuri Chalasani, Jayakumar Singh Bondili, Venkateswara ACCESSORYREAD GLS Rao Talluri Department of Biotechnology, K L University, Guntur, India Background: Obesity is a progressive metabolic disorder in the current world population, and is characterized by the excess deposition of fat in the adipo

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Experimental and Numerical Study on Mechanical Properties and Deformation Behavior of Beishan Granite considering Heterogeneity

Disposal of high-level radioactive waste (HLW) deep underground is one of the most challenging research subjects in rock engineering.In China, Beishan granite is usually chosen as host rock for the construction of the HLW repository.In this study, mechanical tests Bandages are conducted on Beishan granite and the stress-strain state during the comp

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Randomized controlled trial on analgesic effect of pre-operative fascia iliaca compartment block in geriatric patients with hip fracture

Objective While most geriatric patients with hip fracture benefit from definitive operative treatment, pre-operative pain management is often overlooked.Conventional oral analgesics may provide suboptimal pain control, resulting in poor morbidity outcomes.Fascia iliaca compartment block (FICB) provides a more consistent analgesic effect.This study

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